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UniProt P28887

RNA-directed RNA polymerase L (P28887)

RNA-directed RNA polymerase L (UniProt P28887), EC 2.1.1.375, 2.1.1.56: 5 experimental structures on GenesisL1, 2 ligands bound, 76 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
P28887
Protein
RNA-directed RNA polymerase L
EC
2.1.1.375, 2.1.1.56, 2.7.7.-, 2.7.7.48, 2.7.7.88, 3.6.1.-
Experimental structures
5
Predicted models
0
Ligands
2
Pockets
76 · 4 records with a druggable one

Structures

5 records of P28887 in the MolNFT archive: 5 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
6PZKCryo-EM Structure of the Respiratory Syncytial Virus Polymerase (L) Protein Bound by the Tetrameric…electron microscopyA—19 (best 0.79)
6PZKCryo-EM structure of the respiratory syncytial virus polymerase (L) protein bound by the tetrameric…electron microscopyA——
8FPICo-structure of the Respiratory Syncytial Virus RNA-dependent RNA polymerase with MRK-1electron microscopyAY6L19 (best 0.77)
8FU3Structure Of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitorelectron microscopyAYBK19 (best 0.73)
8SNXCryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the leader promoterelectron microscopyA—19 (best 0.83)

Ligands

  • Y6L · 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide · in 1 record
  • YBK · 8-methoxy-3-methyl-N-{(2S)-3,3,3-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-hydroxypropyl}cinnoline-6-carboxamide · in 1 record

Elsewhere

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