Research workbench
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide
Analyse Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PZ9
- Type
- protein
- Length
- 1,196 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-binding cassette sub-family C member 8; ATP-sensitive inward rectifier potassium…
- UniProt
- Q09427, P70673
- Ligands
- BJX, ATP
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 2 distinct chains · 61% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | ATP-binding cassette sub-family C member 8 | protein | 1177 | 62% helix, 7% strand | Q09427 |
| D | ATP-sensitive inward rectifier potassium channel 11 | protein | 19 | 0% helix, 0% strand | P70673 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1156 | 0.89 | 0.90 | 133 | BJX |
| 2 | 1143 | 0.83 | 0.84 | 140 | empty |
| 3 | 1133 | 0.81 | 0.82 | 147 | empty |
| 4 | 433 | 0.80 | 0.88 | 69 | empty |
| 5 | 643 | 0.79 | 0.84 | 67 | empty |
Interfaces
1 interface between chains.
- C–D · 936 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6PZ9 · Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide · the same entry in another collection · chain C against C, TM-score 1.00
- Q09427 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 8 (Q09427) · a predicted model of the same protein · chain C against A, TM-score 0.97
- P70673 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain D against A, TM-score 0.14
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09427
- Every structure of UniProt P70673
- Elsewhere: RCSB PDB 6PZ9 · PDBe 6PZ9 · UniProt Q09427 · UniProt P70673
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