Research workbench
Anti-tau BIIB092 Fab with tau peptide
Analyse Anti-tau BIIB092 Fab with tau peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PXR
- Type
- protein
- Length
- 438 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gosuranemab Fab, light chain; Gosuranemab Fab, heavy chain; Microtubule-associated…
- UniProt
- A2NHM3, P10636
- Pockets
- 6 · best druggability 0.58
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Gosuranemab Fab, light chain | protein | 218 | 6% helix, 51% strand | A2NHM3 |
| H | Gosuranemab Fab, heavy chain | protein | 212 | 7% helix, 50% strand | — |
| A | Microtubule-associated protein tau | protein | 8 | 0% helix, 0% strand | P10636 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 369 | 0.58 | 0.75 | 48 | empty |
| 2 | 103 | 0.37 | 0.74 | 29 | empty |
| 3 | 87 | 0.37 | 0.75 | 17 | empty |
| 4 | 78 | 0.34 | 0.75 | 18 | empty |
| 5 | 65 | 0.31 | 0.75 | 13 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1840 Ų buried · 16 hydrogen bonds · protein-protein
- H–A · 398 Ų buried · 12 hydrogen bonds · protein-protein
- L–A · 199 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6PXR · Anti-TAU BIIB092 FAB with TAU peptide · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A2NHM3
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 6PXR · PDBe 6PXR · UniProt A2NHM3 · UniProt P10636
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