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Human casein kinase 1 delta (anion-free crystallization conditions)

Analyse Human casein kinase 1 delta (anion-free crystallization conditions) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6PXO
Type: protein
Length: 583 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Casein kinase I isoform delta
EC: 2.7.11.1, 2.7.11.26
UniProt: P48730
Pockets: 7 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Casein kinase I isoform delta (EC 2.7.11.1, 2.7.11.26)	protein	291	38% helix, 19% strand	P48730
B	Casein kinase I isoform delta (EC 2.7.11.1, 2.7.11.26)	protein	292	35% helix, 20% strand	P48730

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	324	0.67	0.82	69	empty
2	175	0.60	0.83	35	empty
3	51	0.55	0.90	15	empty
4	69	0.39	0.79	17	empty
5	54	0.35	0.78	13	empty

Interfaces

1 interface between chains.

A–B · 1416 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6PXO · Human Casein Kinase 1 delta (anion-free crystallization conditions) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48730
Elsewhere: RCSB PDB 6PXO · PDBe 6PXO · UniProt P48730

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