Research workbench

Human casein kinase 1 delta tau mutant (R178C)

Analyse Human casein kinase 1 delta tau mutant (R178C) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6PXN
Type: protein
Length: 580 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Casein kinase I isoform delta
EC: 2.7.11.1, 2.7.11.26
UniProt: P48730
Ligands: SO4
Pockets: 5 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Casein kinase I isoform delta (EC 2.7.11.1, 2.7.11.26)	protein	290	38% helix, 20% strand	P48730
B	Casein kinase I isoform delta (EC 2.7.11.1, 2.7.11.26)	protein	290	39% helix, 19% strand	P48730

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	288	0.69	0.84	56	empty
2	185	0.60	0.82	39	empty
3	54	0.59	0.91	15	empty
4	92	0.51	0.83	17	empty
5	84	0.38	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 1496 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

6PXN · Human Casein Kinase 1 delta Tau mutant (R178C) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48730
Elsewhere: RCSB PDB 6PXN · PDBe 6PXN · UniProt P48730

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.