RNase a in complex with CP4PA

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 35% strand (DSSP).

Ligands and binding sites

• OZV · 5'-O-[(R)-hydroxy{[(4r,8s)-4,6,8-trihydroxy-2,4,6,8-tetraoxo-1,3,5,7,2lambda~5~,4lambda~5~,6lambda~5~, 8lambda~5~-tetroxatetraphosphocan-2-yl]oxy}phosphoryl]adenosine · ligand · chains A
• P0J · 2,4,6,8-tetrahydroxy-1,3,5,7,2lambda~5~,4lambda~5~, 6lambda~5~,8lambda~5~-tetroxatetraphosphocane-2,4,6,8-tetrone · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 305 Ų buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide, 1 covalent (disulfide, covalent ligand).

Compared structures

• 6PVW · RNase A in complex with cp4pA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P61823
• Elsewhere: RCSB PDB 6PVW · PDBe 6PVW · UniProt P61823