Research workbench

Human TRPM2 in the apo state

Analyse Human TRPM2 in the apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6PUO
Type: protein
Length: 5,208 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily M member 2
UniProt: O94759
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 48% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily M member 2	protein	1302	48% helix, 10% strand	O94759

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	823	0.85	0.87	95	empty
2	604	0.84	0.88	71	empty
3	1173	0.83	0.84	104	empty
4	331	0.78	0.88	48	empty
5	1087	0.77	0.79	116	empty

Interfaces

6 interfaces between chains.

A–D · 2249 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 2246 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 2240 Å² buried · 5 hydrogen bonds · protein-protein
C–D · 2228 Å² buried · 5 hydrogen bonds · protein-protein
B–D · 19 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6PUO · Human TRPM2 in the apo state · the same entry in another collection · chain A against A, TM-score 1.00
O94759 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O94759
Elsewhere: RCSB PDB 6PUO · PDBe 6PUO · UniProt O94759

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.