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Crystal structure of metal-free neub, an N-acetylneuraminate synthase from neisseria meningitidis in complex with malate
Analyse Crystal structure of metal-free neub, an N-acetylneuraminate synthase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PPX
- Type
- protein
- Length
- 348 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-acetylneuraminate synthase
- EC
- 2.5.1.56
- UniProt
- H2VFG5
- Ligands
- MLT
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-acetylneuraminate synthase (EC 2.5.1.56) | protein | 348 | 40% helix, 19% strand | H2VFG5 |
Ligands and binding sites
- MLT · D-malate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 314 | 0.66 | 0.81 | 34 | MLT |
Compared structures
- 6PPX · Crystal structure of metal-free NeuB, an N-acetylneuraminate synthase from Neisseria… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H2VFG5
- Elsewhere: RCSB PDB 6PPX · PDBe 6PPX · UniProt H2VFG5
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