Research workbench
Crystal structure of the SS2A splice insert-containing neurexin-1 LNS2 domain in complex with neurexophilin-1
Analyse Crystal structure of the SS2A splice insert-containing neurexin-1 LNS2 domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PNQ
- Type
- protein
- Length
- 327 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurexin-1; Neurexophilin-1
- UniProt
- Q9CS84, Q63366
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neurexin-1 | protein | 194 | 4% helix, 50% strand | Q9CS84 |
| B | Neurexophilin-1 | protein | 133 | 0% helix, 64% strand | Q63366 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 126 | 0.39 | 0.75 | 29 | empty |
| 2 | 60 | 0.33 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1258 Ų buried · 39 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6PNQ · Crystal structure of the SS2A splice insert-containing neurexin-1 LNS2 domain in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- Q63366 · AlphaFold monomer V2.0 prediction for neurexophilin-1 (Q63366) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q9CS84 · AlphaFold monomer V2.0 prediction for neurexin-1 (Q9CS84) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9CS84
- Every structure of UniProt Q63366
- Elsewhere: RCSB PDB 6PNQ · PDBe 6PNQ · UniProt Q9CS84 · UniProt Q63366
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