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Structure of mortalin-nbd with adenosine-5'-monophosphate and thiodiphosphate

Analyse Structure of mortalin-nbd with adenosine-5'-monophosphate and thiodiphosphate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6PMT
Type
protein
Length
376 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Stress-70 protein, mitochondrial
UniProt
P38646
Ligands
AMP, PIS, PO4
Pockets
1 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 29% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AStress-70 protein, mitochondrialprotein37641% helix, 29% strandP38646

Ligands and binding sites

  • AMP · Adenosine monophosphate · ligand · chains A
  • PIS · Trihydrogen thiodiphosphate · ligand · chains A
  • PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
16250.750.8273AMP, PIS

Compared structures

  • 6PMT · Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate · the same entry in another collection · chain A against A, TM-score 1.00
  • P38646 · AlphaFold monomer V2.0 prediction for stress-70 protein, mitochondrial (P38646) · a predicted model of the same protein · chain A against A, TM-score 0.88

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