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Cryoem structure of zebra fish alpha-1 glycine receptor bound with GABA in sma, desensitized state
Analyse Cryoem structure of zebra fish alpha-1 glycine receptor bound with GABA in sma… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PLX
- Type
- protein
- Length
- 1,730 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycine receptor subunit ALPHAZ1
- UniProt
- O93430
- Ligands
- ABU, NAG, BMA
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 32% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Glycine receptor subunit ALPHAZ1 | protein | 346 | 32% helix, 28% strand | O93430 |
Ligands and binding sites
- ABU · Gamma-amino-butanoic acid · ligand · 5 copies · chains A, E, B, C, D
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 10 copies · chains A, B, C, D, E
- BMA · beta-D-mannopyranose · sugar · 5 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1043 | 0.82 | 0.83 | 96 | empty |
| 2 | 575 | 0.71 | 0.80 | 74 | empty |
| 3 | 490 | 0.71 | 0.81 | 64 | empty |
| 4 | 463 | 0.71 | 0.81 | 61 | empty |
| 5 | 456 | 0.71 | 0.81 | 60 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2515 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 2513 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 2506 Ų buried · 11 hydrogen bonds · protein-protein
- D–E · 2506 Ų buried · 11 hydrogen bonds · protein-protein
- A–E · 2493 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 5 glycan (disulfide, N-glycosylation).
Compared structures
- 6PLX · CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA… · the same entry in another collection · chain E against E, TM-score 1.00
- O93430 · AlphaFold monomer V2.0 prediction for glycine receptor subunit ALPHAZ1 (O93430) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O93430
- Elsewhere: RCSB PDB 6PLX · PDBe 6PLX · UniProt O93430
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