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Crystal structure of the legionella effector protein mave

Analyse Crystal structure of the legionella effector protein mave in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6PIR
Type: protein
Length: 401 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mave
UniProt: Q5ZT21
Pockets: 6 · best druggability 0.76

Structure

x-ray diffraction · 3 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mave	protein	132	74% helix, 0% strand	Q5ZT21
B	Mave	protein	137	74% helix, 0% strand	Q5ZT21
C	Mave	protein	132	77% helix, 0% strand	Q5ZT21

Ligands and binding sites

CIT · Citric acid · additive · 2 copies · chains B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1190	0.76	0.79	79	empty
2	159	0.47	0.77	20	CIT
3	156	0.45	0.76	24	empty
4	67	0.32	0.76	19	empty
5	80	0.29	0.72	18	empty

Interfaces

3 interfaces between chains.

B–C · 1126 Å² buried · 31 hydrogen bonds · protein-protein
A–C · 361 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 108 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6PIR · Crystal structure of the Legionella effector protein MavE · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5ZT21
Elsewhere: RCSB PDB 6PIR · PDBe 6PIR · UniProt Q5ZT21

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