Research workbench
Crystal structure of human HUWE1 wwe domain in complex with adpr
Analyse Crystal structure of human HUWE1 wwe domain in complex with adpr in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PFL
- Type
- protein
- Length
- 153 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase HUWE1
- EC
- 2.3.2.26
- UniProt
- Q7Z6Z7
- Ligands
- APR, UNX
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) | protein | 76 | 16% helix, 43% strand | Q7Z6Z7 |
| B | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) | protein | 77 | 16% helix, 40% strand | Q7Z6Z7 |
Ligands and binding sites
- APR · Adenosine-5-diphosphoribose · ligand · 2 copies · chains A, B
- UNX · Unknown atom or ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.41 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 402 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6PFL · Crystal structure of Human HUWE1 WWE domain in complex with ADPR · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z6Z7
- Elsewhere: RCSB PDB 6PFL · PDBe 6PFL · UniProt Q7Z6Z7
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