Research workbench

Structure of mouse importin alpha - PAC3 nls peptide complex

Analyse Structure of mouse importin alpha - PAC3 nls peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6P6E
Type: protein
Length: 438 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; PAC3 nls
UniProt: P52293, A0A0B0E960
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 3 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-1	protein	426	72% helix, 0% strand	P52293
B	PAC3 nls	protein	7	0% helix, 0% strand	A0A0B0E960
C	PAC3 nls	protein	5	0% helix, 0% strand	A0A0B0E960

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.46	0.82	12	empty
2	56	0.36	0.79	19	empty

Interfaces

2 interfaces between chains.

A–B · 670 Å² buried · 21 hydrogen bonds · protein-protein
A–C · 475 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

6P6E · Structure of Mouse Importin alpha - PAC3 NLS peptide complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Every structure of UniProt A0A0B0E960
Elsewhere: RCSB PDB 6P6E · PDBe 6P6E · UniProt P52293 · UniProt A0A0B0E960

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.