Research workbench
Structure of spastin aaa domain (T692A mutant) in complex with jnj- 7706621 inhibitor
Analyse Structure of spastin aaa domain (T692A mutant) in complex with jnj- 7706621… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6P11
- Type
- protein
- Length
- 280 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Drosophila melanogaster spastin aaa domain
- EC
- 5.6.1.1
- UniProt
- Q8I0P1
- Ligands
- SKE, SO4
- Pockets
- 3 · best druggability 0.46
Structure
x-ray diffraction · 1 distinct chain · 55% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Drosophila melanogaster spastin aaa domain (EC 5.6.1.1) | protein | 280 | 55% helix, 10% strand | Q8I0P1 |
Ligands and binding sites
- SKE · 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide · ligand · chains B
- SO4 · Sulfate ion · ion · chains B
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.46 | 0.78 | 19 | SKE |
| 2 | 108 | 0.46 | 0.79 | 21 | empty |
| 3 | 59 | 0.32 | 0.76 | 13 | MPD |
Compared structures
- 6P11 · Structure of spastin AAA domain (T692A mutant) in complex with JNJ-7706621 inhibitor · the same entry in another collection · chain B against B, TM-score 1.00
- Q8I0P1 · AlphaFold monomer V2.0 prediction for spastin (Q8I0P1) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8I0P1
- Elsewhere: RCSB PDB 6P11 · PDBe 6P11 · UniProt Q8I0P1
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