UniProt Q8I0P1
Spastin (Q8I0P1)
Spastin (UniProt Q8I0P1), EC 5.6.1.1: 14 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8I0P1
- Protein
- Spastin
- EC
- 5.6.1.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 23 · 5 records with a druggable one
Structures
15 records of Q8I0P1 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6NYV | Structure of spastin AAA domain in complex with a quinazoline-based inhibitor | x-ray diffraction | B | SO4, LBD | — |
| 6NYV | Structure of spastin aaa domain in complex with a quinazoline-based inhibitor | x-ray diffraction | B | SO4, LBD | — |
| 6NYW | Structure of spastin AAA domain N527C mutant in complex with 8-fluoroquinazoline-based inhibitor | x-ray diffraction | B | SO4, L8M | 3 (best 0.50) |
| 6NYW | Structure of spastin aaa domain N527C mutant in complex with 8- fluoroquinazoline-based inhibitor | x-ray diffraction | B | SO4, L8M | — |
| 6P10 | Structure of spastin AAA domain (N527C mutant) in complex with JNJ-7706621 inhibitor | x-ray diffraction | B | SO4, SKE | 2 (best 0.53) |
| 6P10 | Structure of spastin aaa domain (N527C mutant) in complex with jnj- 7706621 inhibitor | x-ray diffraction | B | SO4, SKE | — |
| 6P11 | Structure of spastin AAA domain (T692A mutant) in complex with JNJ-7706621 inhibitor | x-ray diffraction | B | SO4, SKE | 3 (best 0.46) |
| 6P11 | Structure of spastin aaa domain (T692A mutant) in complex with jnj- 7706621 inhibitor | x-ray diffraction | B | SO4, SKE | — |
| 6P12 | Structure of spastin AAA domain (wild-type) in complex with diaminotriazole-based inhibitor | x-ray diffraction | B | NKY, SO4 | 3 (best 0.56) |
| 6P12 | Structure of spastin aaa domain (wild-type) in complex with diaminotriazole-based inhibitor | x-ray diffraction | B | NKY, SO4 | — |
| 6P13 | Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor… | x-ray diffraction | B | SO4, NKY | 3 (best 0.75) |
| 6P13 | Structure of spastin aaa domain (T692A mutant) in complex with a diaminotriazole-based inhibitor… | x-ray diffraction | B | SO4, NKY | — |
| 6P14 | Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor… | x-ray diffraction | A | SO4, NKY | 4 (best 0.56) |
| 6P14 | Structure of spastin aaa domain (T692A mutant) in complex with a diaminotriazole-based inhibitor… | x-ray diffraction | A | SO4, NKY | — |
| Q8I0P1 | AlphaFold monomer V2.0 prediction for spastin (Q8I0P1) | predicted | A | — | 5 (best 0.58) |
Ligands
- SO4 · Sulfate ion · in 14 records
- NKY · 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide · in 6 records
- SKE · 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide · in 4 records
- L8M · N-(5-tert-butyl-1H-pyrazol-3-yl)-8-fluoro-2-[(2R)-2-methylpiperazin-1-yl]quinazolin-4-amine · in 2 records
- LBD · N-(3-tert-butyl-1H-pyrazol-5-yl)-2-[(2R)-2-methylpiperazin-1-yl]quinazolin-4-amine · in 2 records
Experiment against prediction
- 6P14 chain A against the predicted model Q8I0P1: TM-score 0.96, RMSD 1.22 Å
- 6P14 chain A against the predicted model Q8I0P1: TM-score 0.96, RMSD 1.22 Å
- 6P13 chain B against the predicted model Q8I0P1: TM-score 0.94, RMSD 1.80 Å
- 6P13 chain B against the predicted model Q8I0P1: TM-score 0.94, RMSD 1.80 Å
- 6P11 chain B against the predicted model Q8I0P1: TM-score 0.94, RMSD 1.83 Å
- 6P11 chain B against the predicted model Q8I0P1: TM-score 0.94, RMSD 1.83 Å
- 6P12 chain B against the predicted model Q8I0P1: TM-score 0.94, RMSD 1.87 Å
- 6P12 chain B against the predicted model Q8I0P1: TM-score 0.94, RMSD 1.87 Å
- 6NYV chain B against the predicted model Q8I0P1: TM-score 0.94, RMSD 1.93 Å
- 6NYV chain B against the predicted model Q8I0P1: TM-score 0.94, RMSD 1.93 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.