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Crystal structure of a human cardiac calsequestrin filament

Analyse Crystal structure of a human cardiac calsequestrin filament in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6OWV
Type: protein
Length: 329 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calsequestrin-2
UniProt: O14958
Ligands: CL, SO4
Pockets: 2 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calsequestrin-2	protein	329	36% helix, 19% strand	O14958

Ligands and binding sites

CL · Chloride ion · ion · 25 copies · chains A
SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	363	0.63	0.78	40	CL
2	88	0.36	0.75	20	empty

Compared structures

6OWV · Crystal structure of a Human Cardiac Calsequestrin Filament · the same entry in another collection · chain A against A, TM-score 1.00
O14958 · AlphaFold monomer V2.0 prediction for calsequestrin-2 (O14958) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14958
Elsewhere: RCSB PDB 6OWV · PDBe 6OWV · UniProt O14958

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