Research workbench
Zn-mediated polymerization of human sfpq
Analyse Zn-mediated polymerization of human sfpq in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OWJ
- Type
- protein
- Length
- 496 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Splicing factor, proline- and glutamine-rich
- UniProt
- P23246
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Splicing factor, proline- and glutamine-rich | protein | 252 | 40% helix, 21% strand | P23246 |
| B | Splicing factor, proline- and glutamine-rich | protein | 244 | 40% helix, 22% strand | P23246 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 877 | 0.77 | 0.80 | 83 | empty |
| 2 | 201 | 0.48 | 0.76 | 24 | empty |
| 3 | 136 | 0.40 | 0.74 | 19 | empty |
| 4 | 100 | 0.34 | 0.73 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 4759 Ų buried · 82 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23246
- Elsewhere: RCSB PDB 6OWJ · PDBe 6OWJ · UniProt P23246
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