Research workbench
Globin sensor domain of afgchk in monomeric form, with imidazole
Analyse Globin sensor domain of afgchk in monomeric form, with imidazole in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OTD
- Type
- protein
- Length
- 153 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Globin-coupled histidine kinase
- EC
- 2.7.13.3
- UniProt
- A7HD43
- Ligands
- HEM
- Pockets
- 1 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Globin-coupled histidine kinase (EC 2.7.13.3) | protein | 153 | 83% helix, 0% strand | A7HD43 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
- IMD · Imidazole · additive · 2 copies · chains A
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 348 | 0.72 | 0.83 | 35 | HEM, IMD |
Compared structures
- 6OTD · Globin sensor domain of AfGcHK in monomeric form, with imidazole · the same entry in another collection · chain A against A, TM-score 1.00
- A7HD43 · AlphaFold monomer V2.0 prediction for globin-coupled histidine kinase (A7HD43) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7HD43
- Elsewhere: RCSB PDB 6OTD · PDBe 6OTD · UniProt A7HD43
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