UniProt A7HD43
Globin-coupled histidine kinase (A7HD43)
Globin-coupled histidine kinase (UniProt A7HD43), EC 2.7.13.3: 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- A7HD43
- Protein
- Globin-coupled histidine kinase
- EC
- 2.7.13.3
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 18 · 2 records with a druggable one
Structures
7 records of A7HD43 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5OHE | Globin sensor domain of AfGcHK (FeIII form) in complex with cyanide | x-ray diffraction | A, B, C, D, E, F, G, H | HEM, CYN, CL, NA | 17 (best 0.79) |
| 5OHE | Globin sensor domain of afgchk (feiii form) in complex with cyanide | x-ray diffraction | A, B, C, D, E, F, G, H | HEM, CYN, CL, NA | — |
| 5OHF | Globin sensor domain of AfGcHK (FeIII form) in complex with cyanide, partially reduced | x-ray diffraction | A, B, C, D, E, F, G, H | HEM, CYN, CL, NA | — |
| 5OHF | Globin sensor domain of afgchk (feiii form) in complex with cyanide, partially reduced | x-ray diffraction | A, B, C, D, E, F, G, H | HEM, CYN, CL, NA | — |
| 6OTD | Globin sensor domain of AfGcHK in monomeric form, with imidazole | x-ray diffraction | A | HEM | 1 (best 0.72) |
| 6OTD | Globin sensor domain of afgchk in monomeric form, with imidazole | x-ray diffraction | A | HEM | — |
| A7HD43 | AlphaFold monomer V2.0 prediction for globin-coupled histidine kinase (A7HD43) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5OHF chain E against the predicted model A7HD43: TM-score 0.99, RMSD 0.50 Å
- 5OHF chain E against the predicted model A7HD43: TM-score 0.99, RMSD 0.50 Å
- 5OHE chain E against the predicted model A7HD43: TM-score 0.99, RMSD 0.50 Å
- 5OHE chain E against the predicted model A7HD43: TM-score 0.99, RMSD 0.50 Å
- 5OHF chain C against the predicted model A7HD43: TM-score 0.99, RMSD 0.50 Å
- 5OHF chain C against the predicted model A7HD43: TM-score 0.99, RMSD 0.50 Å
- 5OHF chain B against the predicted model A7HD43: TM-score 0.99, RMSD 0.51 Å
- 5OHF chain B against the predicted model A7HD43: TM-score 0.99, RMSD 0.51 Å
- 5OHE chain B against the predicted model A7HD43: TM-score 0.99, RMSD 0.52 Å
- 5OHE chain B against the predicted model A7HD43: TM-score 0.99, RMSD 0.52 Å
Elsewhere
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