Research workbench
Cryo-EM structure of the N-terminally acetylated C-terminal alpha- synuclein truncation AC1-103
Analyse Cryo-EM structure of the N-terminally acetylated C-terminal alpha- synuclein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OSM
- Type
- protein
- Length
- 600 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-synuclein
- UniProt
- P37840
- Pockets
- 4 · best druggability 0.72
Structure
electron microscopy · 1 distinct chain · 0% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Alpha-synuclein | protein | 60 | 0% helix, 38% strand | P37840 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 200 | 0.72 | 0.88 | 37 | empty |
| 2 | 206 | 0.71 | 0.88 | 39 | empty |
| 3 | 274 | 0.64 | 0.82 | 36 | empty |
| 4 | 252 | 0.63 | 0.81 | 31 | empty |
Interfaces
23 interfaces between chains.
- A–C · 2270 Ų buried · 61 hydrogen bonds · protein-protein
- E–G · 2235 Ų buried · 50 hydrogen bonds · protein-protein
- G–I · 2233 Ų buried · 51 hydrogen bonds · protein-protein
- H–J · 2229 Ų buried · 50 hydrogen bonds · protein-protein
- F–H · 2228 Ų buried · 49 hydrogen bonds · protein-protein
Compared structures
- 6OSM · Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37840
- Elsewhere: RCSB PDB 6OSM · PDBe 6OSM · UniProt P37840
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