Research workbench
Potent and selective antitumor antibody targeting a membrane-proximal epitope of ROR2
Analyse Potent and selective antitumor antibody targeting a membrane-proximal epitope… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OSH
- Type
- protein
- Length
- 308 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody light chain variable region; Tyrosine-protein kinase transmembrane receptor…
- EC
- 2.7.10.1
- UniProt
- Q01974
- Pockets
- 3 · best druggability 0.38
Structure
x-ray diffraction · 3 distinct chains · 4% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Antibody light chain variable region | protein | 113 | 3% helix, 47% strand | — |
| K | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) | protein | 81 | 7% helix, 19% strand | Q01974 |
| H | Antibody heavy chain variable region | protein | 114 | 3% helix, 49% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 88 | 0.38 | 0.77 | 25 | empty |
| 2 | 85 | 0.37 | 0.77 | 18 | empty |
| 3 | 58 | 0.25 | 0.72 | 23 | empty |
Interfaces
3 interfaces between chains.
- L–H · 910 Ų buried · 12 hydrogen bonds · protein-protein
- L–K · 501 Ų buried · 12 hydrogen bonds · protein-protein
- K–H · 349 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6OSH · Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2 · the same entry in another collection · chain L against L, TM-score 1.00
- Q01974 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase transmembrane receptor ROR2… · a predicted model of the same protein · chain K against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01974
- Elsewhere: RCSB PDB 6OSH · PDBe 6OSH · UniProt Q01974
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