Research workbench
Reconstituted PP1 holoenzyme
Analyse Reconstituted PP1 holoenzyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OBP
- Type
- protein
- Length
- 583 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase 1…
- EC
- 3.1.3.16
- UniProt
- P62136, Q15435
- Ligands
- MN, CL, PO4
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase PP1-alpha catalytic subunit (EC 3.1.3.16) | protein | 298 | 33% helix, 19% strand | P62136 |
| C | Protein phosphatase 1 regulatory subunit 7 | protein | 285 | 7% helix, 14% strand | Q15435 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · chains A
- CL · Chloride ion · ion · 3 copies · chains A, C
- PO4 · Phosphate ion · ion · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 149 | 0.64 | 0.87 | 27 | empty |
| 2 | 240 | 0.50 | 0.75 | 42 | empty |
| 3 | 177 | 0.42 | 0.73 | 33 | PO4 |
| 4 | 57 | 0.35 | 0.78 | 13 | empty |
Interfaces
1 interface between chains.
- A–C · 1654 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 6OBP · Reconstituted PP1 holoenzyme · the same entry in another collection · chain A against A, TM-score 1.00
- Q15435 · AlphaFold monomer V2.0 prediction for protein phosphatase 1 regulatory subunit 7 (Q15435) · a predicted model of the same protein · chain C against A, TM-score 1.00
- P62136 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase PP1-alpha… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62136
- Every structure of UniProt Q15435
- Elsewhere: RCSB PDB 6OBP · PDBe 6OBP · UniProt P62136 · UniProt Q15435
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