Research workbench

Solution structure of the hoo-bm bound blmt, transposon TN5-encoding bleomycin-binding protein

Analyse Solution structure of the hoo-bm bound blmt, transposon TN5-encoding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1NIQ
Type: protein
Length: 250 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bleomycin resistance protein
UniProt: P13081
Ligands: BLM, CU
Pockets: 5 · best druggability 0.60

Structure

solution nmr · 1 distinct chain · 17% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, C	Bleomycin resistance protein	protein	125	17% helix, 38% strand	P13081

Ligands and binding sites

BLM · Bleomycin A2 · ligand · 2 copies · chains B, C
CU · Copper (II) ion · metal · 2 copies · chains B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.60	0.90	21	empty
2	189	0.53	0.78	26	empty
3	61	0.33	0.76	15	empty
4	67	0.31	0.75	17	empty
5	59	0.30	0.74	16	empty

Interfaces

1 interface between chains.

B–C · 1536 Å² buried · 25 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 11 covalent (covalent ligand).

Compared structures

1NIQ · Solution Structure of the HOO-Bm bound BLMT, Transposon Tn5-encoding Bleomycin-binding… · the same entry in another collection · chain C against C, TM-score 1.00
P13081 · AlphaFold monomer V2.0 prediction for bleomycin resistance protein (P13081) · a predicted model of the same protein · chain C against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13081
Elsewhere: RCSB PDB 1NIQ · PDBe 1NIQ · UniProt P13081

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.