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Ligand · BLM

BLM · Bleomycin A2

BLM, Bleomycin A2 (C55 H85 N17 O21 S3, 1416.6 g/mol), in the MolNFT structures on GenesisL1: bound in 21 records (12 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
BLM
Formula
C55 H85 N17 O21 S3
Class
ligand
Structures
21
PDB entries
12

Binding sites

BLM in 21 structures; the first of them:

  • 1EWJ · Crystal structure of bleomycin-binding protein complexed with bleomycin · BLM A1001 · binds PRO55, LEU56, ALA57, SER58, TRP59, PHE60, SER61, ARG65 and 23 more
  • 1JIE · Crystal structure of bleomycin-binding protein from bleomycin-producing Streptomyces… · BLM A402 · binds ALA59, ASP60, ASN61, THR62, TRP65, GLU67, TYR86, ALA87 and 17 more
  • 1JIF · Crystal structure of bleomycin-binding protein from bleomycin-producing Streptomyces… · BLM B401 · binds ASP32, PHE33, PHE38, HIS49, SER51, ARG52, THR53, ALA259 and 17 more
  • 1MTG · NMR Structure of HO2-Co(III)bleomycin A(2) bound to d(GAGCTC)(2) · BLM B21 · binds DG3, DC4, DT5, DA8, DG9, DC10, DT11, DC12
  • 1MXK · NMR Structure of HO2-Co(III)bleomycin A(2) Bound to d(GGAAGCTTCC)(2) · BLM B21 · binds DG5, DC6, DT7, DA13, DA14, DG15, DC16, DT17 and 2 more
  • 1NIQ · Solution Structure of the HOO-Bm bound BLMT, Transposon Tn5-encoding Bleomycin-binding… · BLM B2402 · binds LEU56, SER58, TRP59, PHE60, CYS63, ARG65, SER85, ARG90 and 20 more
  • 1XRK · Crystal structure of a mutant bleomycin binding protein from Streptoalloteichus… · BLM A402 · binds PRO59, ASP60, ASN61, THR62, GLN63, TRP65, PHE86, ARG87 and 16 more
  • 2A4W · Crystal Structure Of Mitomycin C-Binding Protein Complexed with Copper(II)-Bleomycin A2 · BLM A750 · binds VAL107, TRP108, GLY109, TYR112, PRO128, LEU129, HIS238, ASP252 and 1 more
  • 2A4X · Crystal Structure Of Mitomycin C-Binding Protein Complexed with Metal-Free Bleomycin A2 · BLM A700 · binds HIS71, ALA74, GLU78, TRP108, GLN110, TYR112, ILE114, VAL122 and 9 more
  • 2ZW7 · Crystal structure of bleomycin N-acetyltransferase complexed with bleomycin A2 and… · BLM A402 · binds TRP43, TRP44, THR45, LEU87, GLY88, THR90, VAL92, GLY94 and 19 more
  • 8DW8 · Host-guest structure of BLMA2 partially bound to 5'-ATTAGTTATAACTAAT-3' · BLM G101 · binds DT6, DT7, DA10, DA11
  • 8DWM · Host-guest complex of bleomycin A2 fully bound to CTTAGTTATAACTAAG · BLM G101 · binds DA4, DG5, DT6, DT7, DT9, DA10, DA11, DC12 and 3 more
  • 1EWJ · Crystal structure of bleomycin-binding protein complexed with bleomycin · BLM A1001 · binds PRO55, LEU56, ALA57, SER58, TRP59, PHE60, SER61, ARG65 and 23 more
  • 1JIE · Crystal structure of bleomycin-binding protein from bleomycin- producing streptomyces… · BLM A402 · binds ALA59, ASP60, ASN61, THR62, TRP65, GLU67, TYR86, ALA87 and 17 more
  • 1JIF · Crystal structure of bleomycin-binding protein from bleomycin-producing streptomyces… · BLM B401 · binds ASP32, PHE33, PHE38, HIS49, SER51, ARG52, THR53, ALA259 and 17 more
  • 1MTG · NMR structure of HO2-CO(III)BLEOMYCIN A(2) bound to D(GAGCTC)(2) · BLM B21 · binds DG3, DC4, DT5, DA8, DG9, DC10, DT11, DC12
  • 1MXK · NMR structure of HO2-CO(III)BLEOMYCIN A(2) bound to D(GGAAGCTTCC)(2) · BLM B21 · binds DG5, DC6, DT7, DA13, DA14, DG15, DC16, DT17 and 2 more
  • 1NIQ · Solution structure of the hoo-bm bound blmt, transposon TN5-encoding bleomycin-binding… · BLM B2402 · binds LEU56, SER58, TRP59, PHE60, CYS63, ARG65, SER85, ARG90 and 20 more

Residues it binds most

ARG 38, PHE 38, TRP 40, SER 38, ALA 38, GLY 38, THR 34, GLU 34, LEU 26, ASN 32 (residue and the binding sites it lines).

Found with

  • CU · Copper (II) ion
  • 3CO · Cobalt (III) ion
  • PEO · Hydrogen peroxide
  • COA · Coenzyme A
  • CL · Chloride ion
  • SO4 · Sulfate ion

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