Research workbench

Crystal structure of the actin-binding domain of human alpha-actinin-4

Analyse Crystal structure of the actin-binding domain of human alpha-actinin-4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6OA6
Type: protein
Length: 227 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-actinin-4
UniProt: O43707
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 62% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-actinin-4	protein	227	62% helix, 2% strand	O43707

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.35	0.76	17	empty

Compared structures

6OA6 · Crystal structure of the actin-binding domain of human alpha-actinin-4 · the same entry in another collection · chain A against A, TM-score 1.00
O43707 · AlphaFold monomer V2.0 prediction for alpha-actinin-4 (O43707) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43707
Elsewhere: RCSB PDB 6OA6 · PDBe 6OA6 · UniProt O43707

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.