UniProt O43707
Alpha-actinin-4 (O43707)
Alpha-actinin-4 (UniProt O43707): 8 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43707
- Protein
- Alpha-actinin-4
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 1 · 0 records with a druggable one
Structures
9 records of O43707 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WLX | Solution structure of the third spectrin repeat of alpha-actinin-4 | solution nmr | A | — | — |
| 1WLX | Solution structure of the third spectrin repeat of alpha-actinin-4 | solution nmr | A | — | — |
| 1YDI | Human Vinculin Head Domain (VH1, 1-258) in Complex with Human Alpha-Actinin's Vinculin-Binding Site… | x-ray diffraction | B | — | — |
| 1YDI | Human vinculin head domain (VH1, 1-258) in complex with human alpha-ACTININ'S vinculin-binding site… | x-ray diffraction | B | — | — |
| 2R0O | Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(K255E) | x-ray diffraction | A, B | — | — |
| 2R0O | Crystal structure of the actin-binding domain of human alpha-actinin-4 MUTANT(K255E) | x-ray diffraction | A, B | — | — |
| 6OA6 | Crystal structure of the actin-binding domain of human alpha-actinin-4 | x-ray diffraction | A | — | 1 (best 0.35) |
| 6OA6 | Crystal structure of the actin-binding domain of human alpha-actinin-4 | x-ray diffraction | A | — | — |
| O43707 | AlphaFold monomer V2.0 prediction for alpha-actinin-4 (O43707) | predicted | A | — | — |
Experiment against prediction
- 2R0O chain A against the predicted model O43707: TM-score 0.99, RMSD 0.70 Å
- 2R0O chain A against the predicted model O43707: TM-score 0.99, RMSD 0.70 Å
- 6OA6 chain A against the predicted model O43707: TM-score 0.98, RMSD 0.82 Å
- 6OA6 chain A against the predicted model O43707: TM-score 0.98, RMSD 0.82 Å
- 2R0O chain B against the predicted model O43707: TM-score 0.97, RMSD 1.07 Å
- 2R0O chain B against the predicted model O43707: TM-score 0.97, RMSD 1.07 Å
- 1YDI chain B against the predicted model O43707: TM-score 0.84, RMSD 0.90 Å
- 1YDI chain B against the predicted model O43707: TM-score 0.84, RMSD 0.90 Å
- 1WLX chain A against the predicted model O43707: TM-score 0.81, RMSD 2.57 Å
- 1WLX chain A against the predicted model O43707: TM-score 0.81, RMSD 2.57 Å
Elsewhere
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