MolNFT v1 · #49838 · protein
Crystal structure of the actin-binding domain of human alpha-actinin-4 MUTANT(K255E)
2R0O: “Crystal structure of the actin-binding domain of human alpha-actinin-4 MUTANT(K255E)”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #49838 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2R0O
- Type
- protein
- Length
- 456 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-actinin-4
- UniProt
- O43707
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-actinin-4 | protein | 227 | 60% helix, 2% strand | O43707 |
| B | Alpha-actinin-4 | protein | 229 | 60% helix, 2% strand | O43707 |
Ligands and binding sites
- GOL · Glycerol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 381 | 0.59 | 0.76 | 46 | empty |
| 2 | 250 | 0.54 | 0.77 | 29 | empty |
| 3 | 74 | 0.36 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 348 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2R0O · Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(K255E) · the same entry in another collection · chain A against A, TM-score 1.00
- O43707 · AlphaFold monomer V2.0 prediction for alpha-actinin-4 (O43707) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43707
- Elsewhere: RCSB PDB 2R0O · PDBe 2R0O · UniProt O43707
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.