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The effect of modifier structure on the activation of leukotriene A4 hydrolase aminopeptidase activity.
Analyse The effect of modifier structure on the activation of leukotriene A4 hydrolase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6O5H
- Type
- protein
- Length
- 1,823 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukotriene a-4 hydrolase
- EC
- 3.3.2.6
- UniProt
- P09960
- Ligands
- LNJ, ZN
- Pockets
- 17 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leukotriene a-4 hydrolase (EC 3.3.2.6) | protein | 607 | 43% helix, 23% strand | P09960 |
| B, C | Leukotriene a-4 hydrolase (EC 3.3.2.6) | protein | 608 | 43% helix, 23% strand | P09960 |
Ligands and binding sites
- LNJ · 4-{4-[(4-methoxyphenyl)methyl]phenyl}-1,3-thiazol-2-amine · ligand · 3 copies · chains A, B, C
- ZN · Zinc ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 839 | 0.86 | 0.89 | 82 | LNJ, ZN |
| 2 | 1056 | 0.85 | 0.86 | 98 | LNJ |
| 3 | 1037 | 0.85 | 0.86 | 89 | LNJ |
| 4 | 535 | 0.78 | 0.85 | 82 | empty |
| 5 | 1126 | 0.74 | 0.77 | 89 | empty |
Interfaces
2 interfaces between chains.
- B–C · 633 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 451 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6O5H · The effect of modifier structure on the activation of leukotriene A4 hydrolase… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09960
- Elsewhere: RCSB PDB 6O5H · PDBe 6O5H · UniProt P09960
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