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Structural basis of FOXC2 and DNA interactions

Analyse Structural basis of FOXC2 and DNA interactions in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6O3T
Type: protein + DNA
Length: 202 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Forkhead box protein C2; DNA (5'- D(*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP…
UniProt: Q99958
Pockets: 5 · best druggability 0.57

Structure

x-ray diffraction · 4 distinct chains · 46% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Forkhead box protein C2	protein	95	41% helix, 11% strand	Q99958
C	DNA (5'- D(APAPAPTPTPGPTPTPTPAPTPAPAPAPCPAPGPCPCPCP*G)- 3')	dna	21	—	—
D	DNA (5'- D(TPTPCPGPGPGPCPTPGPTPTPTPAPTPAPAPAPCPAPAP*T)- 3')	dna	21	—	—
B	Forkhead box protein C2	protein	65	54% helix, 12% strand	Q99958

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	164	0.57	0.82	25	empty
2	116	0.35	0.73	21	empty
3	70	0.35	0.77	14	empty
4	89	0.30	0.72	17	empty
5	51	0.23	0.72	14	empty

Interfaces

6 interfaces between chains.

C–D · 850 Å² buried · 80 hydrogen bonds · nucleic-nucleic
A–C · 535 Å² buried · 11 hydrogen bonds · protein-nucleic
D–B · 455 Å² buried · 8 hydrogen bonds · protein-nucleic
A–D · 424 Å² buried · 9 hydrogen bonds · protein-nucleic
C–B · 346 Å² buried · 6 hydrogen bonds · protein-nucleic

Compared structures

6O3T · Structural basis of FOXC2 and DNA interactions · the same entry in another collection · chain A against A, TM-score 1.00
Q99958 · AlphaFold monomer V2.0 prediction for forkhead box protein C2 (Q99958) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99958
Elsewhere: RCSB PDB 6O3T · PDBe 6O3T · UniProt Q99958

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