Research workbench

Bovine salivary protein form 30B with oleic acid

Analyse Bovine salivary protein form 30B with oleic acid in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6O1T
Type: protein
Length: 378 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Short palate, lung and nasal epithelium carcinoma- associated protein 2B
UniProt: P79125
Ligands: OLA, CA
Pockets: 5 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Short palate, lung and nasal epithelium carcinoma- associated protein 2B	protein	192	46% helix, 30% strand	P79125
B	Short palate, lung and nasal epithelium carcinoma- associated protein 2B	protein	186	47% helix, 31% strand	P79125

Ligands and binding sites

OLA · Oleic acid · ligand · 2 copies · chains A, B
CA · Calcium ion · metal · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	194	0.75	0.90	29	OLA
2	294	0.71	0.85	40	empty
3	206	0.69	0.85	30	OLA
4	176	0.49	0.77	25	empty
5	95	0.36	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 799 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

6O1T · Bovine salivary protein form 30B with oleic acid · the same entry in another collection · chain A against A, TM-score 1.00
P79125 · AlphaFold monomer V2.0 prediction for short palate, lung and nasal epithelium… · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P79125
Elsewhere: RCSB PDB 6O1T · PDBe 6O1T · UniProt P79125

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