Research workbench
Human (alpha MET/BETA hemichrome) hemoglobin with S-nitrosation at beta-CYS93
Analyse Human (alpha MET/BETA hemichrome) hemoglobin with S-nitrosation at beta-CYS93 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6NQ5
- Type
- protein
- Length
- 285 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemoglobin subunit alpha; Hemoglobin subunit beta
- UniProt
- P69905, P68871
- Ligands
- HEM, FE
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemoglobin subunit alpha | protein | 140 | 76% helix, 0% strand | P69905 |
| B | Hemoglobin subunit beta | protein | 145 | 77% helix, 0% strand | P68871 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
- FE · Fe (III) ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 247 | 0.73 | 0.87 | 27 | HEM, FE |
| 2 | 201 | 0.73 | 0.88 | 26 | HEM |
| 3 | 127 | 0.52 | 0.81 | 24 | empty |
| 4 | 53 | 0.33 | 0.78 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 917 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (nonstandard).
Compared structures
- 6NQ5 · human (alpha met/beta hemichrome) hemoglobin with S-nitrosation at beta-Cys93 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P69905
- Every structure of UniProt P68871
- Elsewhere: RCSB PDB 6NQ5 · PDBe 6NQ5 · UniProt P69905 · UniProt P68871
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