Research workbench

Hypoxia-inducible factor (hif) prolyl hydroxylase 2 (PHD2) in complex with the carboxamide analog JNJ43058171

Analyse Hypoxia-inducible factor (hif) prolyl hydroxylase 2 (PHD2) in complex with the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6NMQ
Type: protein
Length: 187 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Egl nine homolog 1
EC: 1.14.11.29
UniProt: Q9GZT9
Ligands: KU1, FE2
Pockets: 1 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Egl nine homolog 1 (EC 1.14.11.29)	protein	187	27% helix, 32% strand	Q9GZT9

Ligands and binding sites

KU1 · N-(4-oxo-1,4-dihydrocinnoline-3-carbonyl)glycine · ligand · chains A
FE2 · Fe (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	105	0.64	0.88	19	KU1

Compared structures

6NMQ · Hypoxia-Inducible Factor (HIF) Prolyl Hydroxylase 2 (PHD2) in Complex with the… · the same entry in another collection · chain A against A, TM-score 1.00
Q9GZT9 · AlphaFold monomer V2.0 prediction for egl nine homolog 1 (Q9GZT9) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GZT9
Elsewhere: RCSB PDB 6NMQ · PDBe 6NMQ · UniProt Q9GZT9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.