Research workbench

Designed repeat protein specifically in complex with FZ7CRD

Analyse Designed repeat protein specifically in complex with FZ7CRD in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6NE4
Type: protein
Length: 313 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Designed repeat binding protein; Frizzled-7
UniProt: O75084
Ligands: SO4
Pockets: 3 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Designed repeat binding protein	protein	194	57% helix, 0% strand	—
A	Frizzled-7	protein	119	40% helix, 9% strand	O75084

Ligands and binding sites

SO4 · Sulfate ion · ion · 14 copies · chains B, A
EDO · 1,2-ethanediol · additive · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.45	0.78	22	SO4
2	64	0.32	0.75	16	SO4
3	63	0.31	0.75	17	empty

Interfaces

1 interface between chains.

B–A · 1137 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6NE4 · Designed repeat protein specifically in complex with Fz7CRD · the same entry in another collection · chain B against B, TM-score 1.00
O75084 · AlphaFold monomer V2.0 prediction for frizzled-7 (O75084) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75084
Elsewhere: RCSB PDB 6NE4 · PDBe 6NE4 · UniProt O75084

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.