Research workbench
Crystal structure of the human cell polarity protein lethal giant larvae 2 (LGL2). apkc phosphorylated, crystal form 2.
Analyse Crystal structure of the human cell polarity protein lethal giant larvae 2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N8R
- Type
- protein
- Length
- 831 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LETHAL(2) giant larvae protein homolog 2
- UniProt
- Q6P1M3
- Ligands
- CL
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | LETHAL(2) giant larvae protein homolog 2 | protein | 831 | 8% helix, 48% strand | Q6P1M3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1149 | 0.82 | 0.83 | 80 | empty |
| 2 | 1083 | 0.79 | 0.80 | 62 | empty |
| 3 | 277 | 0.66 | 0.82 | 38 | empty |
| 4 | 158 | 0.42 | 0.74 | 23 | empty |
| 5 | 109 | 0.38 | 0.75 | 19 | empty |
Compared structures
- 6N8R · Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). aPKC… · the same entry in another collection · chain A against A, TM-score 1.00
- Q6P1M3 · AlphaFold monomer V2.0 prediction for llgl scribble cell polarity complex component 2… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P1M3
- Elsewhere: RCSB PDB 6N8R · PDBe 6N8R · UniProt Q6P1M3
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