Research workbench
Resistance to inhibitors of cholinesterase 8A (RIC8A) protein in complex with mbp-tagged transducin-alpha residues 327-350
Analyse Resistance to inhibitors of cholinesterase 8A (RIC8A) protein in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N85
- Type
- protein
- Length
- 796 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Synembryn-a; MALTOSE/MALTODEXTRIN-binding periplasmic PROTEIN,GUANINE nucleotide-binding…
- UniProt
- Q5E9J8, P0AEY0, P19087
- Ligands
- GLC
- Pockets
- 8 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Synembryn-a | protein | 403 | 72% helix, 1% strand | Q5E9J8 |
| M | MALTOSE/MALTODEXTRIN-binding periplasmic PROTEIN,GUANINE nucleotide-binding protein G(T) subunit alpha-2 | protein | 393 | 45% helix, 20% strand | P0AEY0, P19087 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains M
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 921 | 0.71 | 0.76 | 81 | empty |
| 2 | 619 | 0.70 | 0.78 | 53 | GLC |
| 3 | 264 | 0.53 | 0.75 | 34 | empty |
| 4 | 60 | 0.51 | 0.86 | 16 | empty |
| 5 | 117 | 0.48 | 0.80 | 19 | empty |
Interfaces
1 interface between chains.
- B–M · 1466 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6N85 · Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged… · the same entry in another collection · chain B against B, TM-score 1.00
- Q5E9J8 · AlphaFold monomer V2.0 prediction for synembryn-a (Q5E9J8) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P19087 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(T) subunit… · a predicted model of the same protein · chain M against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5E9J8
- Every structure of UniProt P0AEY0
- Every structure of UniProt P19087
- Elsewhere: RCSB PDB 6N85 · PDBe 6N85 · UniProt Q5E9J8 · UniProt P0AEY0 · UniProt P19087
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