Research workbench
Crystal structure of abin-1 uban in complex with two M1-linked di- ubiquitins
Analyse Crystal structure of abin-1 uban in complex with two M1-linked di- ubiquitins in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N6R
- Type
- protein
- Length
- 433 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin; TNFAIP3-interacting protein 1
- UniProt
- P0CG48, Q9WUU8
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 46% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin | protein | 148 | 24% helix, 36% strand | P0CG48 |
| B | TNFAIP3-interacting protein 1 | protein | 68 | 96% helix, 0% strand | Q9WUU8 |
| D | TNFAIP3-interacting protein 1 | protein | 67 | 97% helix, 0% strand | Q9WUU8 |
| C | Ubiquitin | protein | 150 | 21% helix, 36% strand | P0CG48 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 267 | 0.56 | 0.77 | 33 | empty |
| 2 | 108 | 0.34 | 0.72 | 16 | empty |
Interfaces
5 interfaces between chains.
- B–D · 1869 Ų buried · 17 hydrogen bonds · protein-protein
- A–D · 834 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 753 Ų buried · 14 hydrogen bonds · protein-protein
- D–C · 613 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 562 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6N6R · Crystal structure of ABIN-1 UBAN in complex with two M1-linked di-ubiquitins · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WUU8 · AlphaFold monomer V2.0 prediction for TNFAIP3-interacting protein 1 (Q9WUU8) · a predicted model of the same protein · chain D against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0CG48
- Every structure of UniProt Q9WUU8
- Elsewhere: RCSB PDB 6N6R · PDBe 6N6R · UniProt P0CG48 · UniProt Q9WUU8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.