Research workbench
Human histidine triad nucleotide binding protein 1 (HINT1) with bound 5'-O-[(3-indolyl)-1-ETHYL]CARBAMOYL guanosine
Analyse Human histidine triad nucleotide binding protein 1 (HINT1) with bound… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N3Y
- Type
- protein
- Length
- 225 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histidine triad nucleotide-binding protein 1
- UniProt
- P49773
- Ligands
- HHJ, CL
- Pockets
- 2 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histidine triad nucleotide-binding protein 1 | protein | 115 | 29% helix, 24% strand | P49773 |
| B | Histidine triad nucleotide-binding protein 1 | protein | 110 | 30% helix, 25% strand | P49773 |
Ligands and binding sites
- HHJ · 5'-O-{[2-(1H-indol-3-yl)ethyl]carbamoyl}guanosine · ligand · chains A, B
- CL · Chloride ion · ion · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.37 | 0.75 | 27 | HHJ |
| 2 | 82 | 0.35 | 0.75 | 21 | CL |
Interfaces
1 interface between chains.
- A–B · 1991 Ų buried · 46 hydrogen bonds · protein-protein
Compared structures
- 6N3Y · Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49773
- Elsewhere: RCSB PDB 6N3Y · PDBe 6N3Y · UniProt P49773
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.