Research workbench
NMR solution structure of the homodimeric, autoinhibited state of the CARD9 card and first coiled-coil
Analyse NMR solution structure of the homodimeric, autoinhibited state of the CARD9… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N2M
- Type
- protein
- Length
- 284 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Caspase recruitment domain-containing protein 9
- UniProt
- Q9H257
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.45
Structure
solution nmr · 1 distinct chain · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Caspase recruitment domain-containing protein 9 | protein | 142 | 71% helix, 0% strand | Q9H257 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.45 | 0.74 | 26 | empty |
| 2 | 89 | 0.36 | 0.75 | 11 | empty |
| 3 | 58 | 0.32 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1172 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6N2M · NMR solution structure of the homodimeric, autoinhibited state of the CARD9 CARD and… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H257 · AlphaFold monomer V2.0 prediction for caspase recruitment domain- containing protein 9… · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H257
- Elsewhere: RCSB PDB 6N2M · PDBe 6N2M · UniProt Q9H257
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