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Structure of GTPase domain of human septin 7 at high resolution

Analyse Structure of GTPase domain of human septin 7 at high resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6N12
Type: protein
Length: 505 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Septin-7
UniProt: Q16181
Ligands: GDP, MG
Pockets: 8 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Septin-7	protein	251	35% helix, 22% strand	Q16181
B	Septin-7	protein	254	37% helix, 20% strand	Q16181

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1005	0.79	0.80	115	GDP, MG
2	279	0.61	0.80	47	GDP, MG
3	94	0.48	0.81	17	empty
4	52	0.45	0.84	13	empty
5	90	0.45	0.79	19	empty

Interfaces

1 interface between chains.

A–B · 1588 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

6N12 · Structure of GTPase Domain of Human Septin 7 at High Resolution · the same entry in another collection · chain A against A, TM-score 1.00
Q16181 · AlphaFold monomer V2.0 prediction for septin-7 (Q16181) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16181
Elsewhere: RCSB PDB 6N12 · PDBe 6N12 · UniProt Q16181

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