Research workbench
Structure of GTPase domain of human septin 7 at high resolution
Analyse Structure of GTPase domain of human septin 7 at high resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N0B
- Type
- protein
- Length
- 1,016 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Septin-7
- UniProt
- Q16181
- Ligands
- GDP
- Pockets
- 14 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Septin-7 | protein | 256 | 37% helix, 21% strand | Q16181 |
| A | Septin-7 | protein | 250 | 38% helix, 21% strand | Q16181 |
| B | Septin-7 | protein | 257 | 35% helix, 21% strand | Q16181 |
| D | Septin-7 | protein | 253 | 36% helix, 21% strand | Q16181 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 4 copies · chains C, A, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.68 | 0.95 | 26 | empty |
| 2 | 207 | 0.66 | 0.85 | 36 | empty |
| 3 | 61 | 0.63 | 0.92 | 19 | empty |
| 4 | 330 | 0.61 | 0.78 | 61 | GDP |
| 5 | 232 | 0.58 | 0.80 | 42 | GDP |
Interfaces
3 interfaces between chains.
- A–B · 1411 Ų buried · 17 hydrogen bonds · protein-protein
- C–A · 662 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 427 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16181
- Elsewhere: RCSB PDB 6N0B · PDBe 6N0B · UniProt Q16181
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