Research workbench
Structure of the major pilin protein (T-18.1) from streptococcus pyogenes serotype MGAS8232
Analyse Structure of the major pilin protein (T-18.1) from streptococcus pyogenes… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N0A
- Type
- protein
- Length
- 553 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major pilin backbone protein T-antigen
- UniProt
- A0A096ZH83
- Ligands
- CA
- Pockets
- 3 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major pilin backbone protein T-antigen | protein | 278 | 2% helix, 51% strand | A0A096ZH83 |
| B | Major pilin backbone protein T-antigen | protein | 275 | 2% helix, 50% strand | A0A096ZH83 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 747 | 0.76 | 0.81 | 71 | empty |
| 2 | 254 | 0.60 | 0.80 | 26 | empty |
| 3 | 251 | 0.60 | 0.79 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1117 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 isopeptide (isopeptide).
Compared structures
- 6N0A · Structure of the major pilin protein (T-18.1) from Streptococcus pyogenes serotype… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A096ZH83
- Elsewhere: RCSB PDB 6N0A · PDBe 6N0A · UniProt A0A096ZH83
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