Research workbench
Crystal structure of the denr-mct-1 complex
Analyse Crystal structure of the denr-mct-1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MS4
- Type
- protein
- Length
- 227 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Malignant T-cell-amplified sequence 1; Density-regulated protein
- UniProt
- Q9ULC4, O43583
- Ligands
- NA, ZN
- Pockets
- 2 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Malignant T-cell-amplified sequence 1 | protein | 181 | 27% helix, 28% strand | Q9ULC4 |
| B | Density-regulated protein | protein | 46 | 48% helix, 4% strand | O43583 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
- ZN · Zinc ion · metal · chains B
- PGE · Triethylene glycol · additive · 3 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.41 | 0.79 | 23 | empty |
| 2 | 60 | 0.37 | 0.79 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 856 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6MS4 · Crystal structure of the DENR-MCT-1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9ULC4 · AlphaFold monomer V2.0 prediction for malignant T-cell-amplified sequence 1 (Q9ULC4) · a predicted model of the same protein · chain A against A, TM-score 0.95
- O43583 · AlphaFold monomer V2.0 prediction for density-regulated protein (O43583) · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ULC4
- Every structure of UniProt O43583
- Elsewhere: RCSB PDB 6MS4 · PDBe 6MS4 · UniProt Q9ULC4 · UniProt O43583
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.