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Crystal structure of GTPase domain of human septin 12 in complex with gmppnp in space group C2221

Analyse Crystal structure of GTPase domain of human septin 12 in complex with gmppnp in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6MQB
Type: protein
Length: 267 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Septin-12
UniProt: Q8IYM1
Ligands: GNP, MG
Pockets: 3 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Septin-12	protein	267	37% helix, 21% strand	Q8IYM1

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.42	0.78	25	GNP, MG
2	77	0.40	0.79	12	empty
3	52	0.30	0.75	11	empty

Compared structures

6MQB · Crystal Structure of GTPase Domain of Human Septin 12 in complex with GMPPNP in Space… · the same entry in another collection · chain A against A, TM-score 1.00
Q8IYM1 · AlphaFold monomer V2.0 prediction for septin-12 (Q8IYM1) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IYM1
Elsewhere: RCSB PDB 6MQB · PDBe 6MQB · UniProt Q8IYM1

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