Research workbench

Substrate free cytochrome P450 3A5 (CYP3A5)

Analyse Substrate free cytochrome P450 3A5 (CYP3A5) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6MJM
Type: protein
Length: 453 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P450 3A5
EC: 1.14.14.1
UniProt: P20815
Ligands: HEM
Pockets: 5 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P450 3A5 (EC 1.14.14.1)	protein	453	52% helix, 9% strand	P20815

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1177	0.86	0.86	91	HEM, GOL
2	173	0.59	0.82	25	empty
3	200	0.47	0.74	32	empty
4	151	0.45	0.75	24	empty
5	53	0.25	0.73	21	empty

Compared structures

6MJM · Substrate Free Cytochrome P450 3A5 (CYP3A5) · the same entry in another collection · chain A against A, TM-score 1.00
P20815 · AlphaFold monomer V2.0 prediction for cytochrome P450 3A5 (P20815) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20815
Elsewhere: RCSB PDB 6MJM · PDBe 6MJM · UniProt P20815

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