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Human TRPM2 ion channel in apo state

Analyse Human TRPM2 ion channel in apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6MIX
Type: protein
Length: 5,348 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily M member 2
UniProt: O94759
Pockets: 20 · best druggability 0.88

Structure

electron microscopy · 1 distinct chain · 41% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily M member 2	protein	1337	41% helix, 8% strand	O94759

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1107	0.88	0.89	132	empty
2	970	0.83	0.84	96	empty
3	777	0.83	0.85	85	empty
4	470	0.82	0.89	63	empty
5	808	0.82	0.85	83	empty

Interfaces

6 interfaces between chains.

A–D · 3880 Å² buried · 36 hydrogen bonds · protein-protein
C–D · 3858 Å² buried · 41 hydrogen bonds · protein-protein
A–B · 3841 Å² buried · 40 hydrogen bonds · protein-protein
B–C · 3807 Å² buried · 45 hydrogen bonds · protein-protein
B–D · 27 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6MIX · Human TRPM2 ion channel in apo state · the same entry in another collection · chain B against B, TM-score 1.00
O94759 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O94759
Elsewhere: RCSB PDB 6MIX · PDBe 6MIX · UniProt O94759

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