Research workbench
Crystal structure of the ilk ATP-binding deficient mutant (L207W) /alpha-parvin core complex
Analyse Crystal structure of the ilk ATP-binding deficient mutant (L207W) /alpha-parvin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MIB
- Type
- protein
- Length
- 394 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrin-linked protein kinase; Alpha-parvin
- EC
- 2.7.11.1
- UniProt
- Q13418, Q9NVD7
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrin-linked protein kinase (EC 2.7.11.1) | protein | 270 | 41% helix, 16% strand | Q13418 |
| B | Alpha-parvin | protein | 124 | 65% helix, 1% strand | Q9NVD7 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 923 | 0.81 | 0.83 | 89 | empty |
| 2 | 87 | 0.44 | 0.80 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 972 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6MIB · Crystal structure of the ILK ATP-binding deficient mutant (L207W)/alpha-parvin core… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NVD7 · AlphaFold monomer V2.0 prediction for alpha-parvin (Q9NVD7) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q13418 · AlphaFold monomer V2.0 prediction for integrin-linked protein kinase (Q13418) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13418
- Every structure of UniProt Q9NVD7
- Elsewhere: RCSB PDB 6MIB · PDBe 6MIB · UniProt Q13418 · UniProt Q9NVD7
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