Research workbench
Structure of human TRPV3 in the presence of 2-apb in C4 symmetry
Analyse Structure of human TRPV3 in the presence of 2-apb in C4 symmetry in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MHV
- Type
- protein
- Length
- 2,452 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 3
- UniProt
- Q8NET8
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 58% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, C, A, D | Transient receptor potential cation channel subfamily V member 3 | protein | 613 | 58% helix, 5% strand | Q8NET8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1159 | 0.85 | 0.85 | 88 | empty |
| 2 | 830 | 0.78 | 0.81 | 117 | empty |
| 3 | 480 | 0.70 | 0.80 | 47 | empty |
| 4 | 338 | 0.70 | 0.82 | 28 | empty |
| 5 | 337 | 0.70 | 0.82 | 31 | empty |
Interfaces
6 interfaces between chains.
- A–D · 2708 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 2706 Ų buried · 13 hydrogen bonds · protein-protein
- B–A · 2699 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 2685 Ų buried · 13 hydrogen bonds · protein-protein
- C–A · 14 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6MHV · Structure of human TRPV3 in the presence of 2-APB in C4 symmetry · the same entry in another collection · chain B against B, TM-score 1.00
- Q8NET8 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NET8
- Elsewhere: RCSB PDB 6MHV · PDBe 6MHV · UniProt Q8NET8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.