Research workbench
GALPHAI3 co-crystallized with GIV/GIRDIN
Analyse GALPHAI3 co-crystallized with GIV/GIRDIN in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MHF
- Type
- protein
- Length
- 348 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(K) subunit alpha; Girdin
- UniProt
- P08753, Q3V6T2
- Ligands
- GDP
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(K) subunit alpha | protein | 330 | 47% helix, 14% strand | P08753 |
| C | Girdin | protein | 18 | 44% helix, 17% strand | Q3V6T2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 626 | 0.71 | 0.79 | 70 | GDP, GOL |
| 2 | 84 | 0.42 | 0.78 | 18 | empty |
Interfaces
1 interface between chains.
- A–C · 777 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 6MHF · Galphai3 co-crystallized with GIV/Girdin · the same entry in another collection · chain A against A, TM-score 1.00
- P08753 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.92
- Q3V6T2 · AlphaFold monomer V2.0 prediction for girdin (Q3V6T2) · a predicted model of the same protein · chain C against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08753
- Every structure of UniProt Q3V6T2
- Elsewhere: RCSB PDB 6MHF · PDBe 6MHF · UniProt P08753 · UniProt Q3V6T2
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