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Crystal structure of rsmd methyltransferase of M. tuberculosis in complex with sinefungin reveals key interactions

Analyse Crystal structure of rsmd methyltransferase of M. tuberculosis in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6M1C
Type: protein
Length: 184 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Possible methyltransferase (methylase)
UniProt: I6XFS7
Ligands: SFG
Pockets: 1 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Possible methyltransferase (methylase)	protein	184	30% helix, 23% strand	I6XFS7

Ligands and binding sites

SFG · Sinefungin · ligand · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	251	0.61	0.80	38	SFG, ACT

Compared structures

6M1C · Crystal structure of RsmD methyltransferase of M. tuberculosis in complex with sinefungin… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I6XFS7
Elsewhere: RCSB PDB 6M1C · PDBe 6M1C · UniProt I6XFS7

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